Hemodynamic and Surgical Outcomes of Perioperative Vasopressin Administration in Laparoscopic Myomectomy Patients

Abstract

This study evaluates the effects of intramyometrial vasopressin on blood loss, transfusion requirements, and cardiovascular responses during surgery. A total of 64 patients were divided into two groups: the Vasopressin group, which received 15 mL of diluted vasopressin between the myometrium and the myoma, and the Control group, which received an equal volume of normal saline. Key indicators such as bradycardia, tachycardia, electrocardiogram abnormalities, blood troponin I levels, blood transfusion requirements, and total blood loss were monitored. Preoperative clinical and demographic characteristics were similar between the groups. Vasopressin administration resulted in a temporary rise in mean arterial blood pressure (peaking at T3) and a significant decrease in heart rate (most notable at T4). Despite a significantly longer operative time in the Control group (395 vs. 110 minutes), both groups had comparable blood loss and transfusion needs. While intramyometrial vasopressin effectively reduces blood loss and transfusion requirements, it is associated with potential cardiovascular risks, necessitating careful monitoring and precautionary measures by gynecologists and anesthesiologists.