Study of Granulomatous Lesions at Various Sites-An Ambispective Study.

Abstract

Background: Granulomatous inflammation is a chronic inflammatory response characterized by the formation of granulomas, which canoccur in response to various infectious and non-infectious stimuli. This study aimed to evaluate the histopathological spectrum, age and gender distribution, and site-wise occurrence of granulomatous lesions.

Methods: This ambispective study analyzed 60 histopathological confirmed cases of granulomatous inflammation over a definite period. Data regarding patient age, gender, and site of the lesion were collected and analyzed.

Conclusion: Granulomatous inflammation is most frequently observed in lymph nodes and breast tissue, particularly in middle- aged females. Tuberculosis is likely the predominant cause in endemic regions. Histopathological study remains crucial in the diagnostic approach to granulomatous conditions.

Results: The most affected age group was 51–60 years (33.3%), with a female predominance (68.3%). The most common site was lymph nodes (68.3%), followed by breast tissue (16.6%) and appendix (5%). Rare sites included the ileocecal junction, endometrium, omentum, testis, gallbladder, and prostate (each 1.6%).